このコースについて
4.7
53件の評価
7件のレビュー

100%オンライン

自分のスケジュールですぐに学習を始めてください。

柔軟性のある期限

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中級レベル

約17時間で修了

推奨:6 weeks of study, 3-5 hours a week...

英語

字幕:英語

100%オンライン

自分のスケジュールですぐに学習を始めてください。

柔軟性のある期限

スケジュールに従って期限をリセットします。

中級レベル

約17時間で修了

推奨:6 weeks of study, 3-5 hours a week...

英語

字幕:英語

シラバス - 本コースの学習内容

1
3時間で修了

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
7件のビデオ (合計54分), 9 readings, 9 quizzes
7件のビデオ
Course Introduction1 分
Anatomy of the Human Genome13 分
Identifying Functionally Important Elements in the Human Reference Genome12 分
Genetic Polymorphism11 分
Interrogating Genetic Variation10 分
Week 1 Conclusion2 分
9件の学習用教材
Meet your Educators and Fellow Learners10 分
Course Navigation10 分
Typos in videos10 分
Recommended Pre-reading10 分
The Human Genome Project30 分
Recommended Pre-reading10 分
Recommended Pre-reading10 分
Recommended Pre-reading10 分
Glossary Week 110 分
9の練習問題
Pre-lecture Questions6 分
Practice Quiz2 分
Pre-lecture Questions4 分
Practice Quiz2 分
Pre-lecture Questions4 分
Practice Quiz4 分
Pre-lecture Questions6 分
Practice Quiz2 分
Introduction. Human Genome8 分
2
4時間で修了

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
7件のビデオ (合計59分), 13 readings, 13 quizzes
7件のビデオ
Hardy-Weinberg Equilibrium8 分
Linkage Disequilibrium8 分
Natural Selection11 分
Genetic Drift9 分
Genetic Structure12 分
Week 2 Conclusion2 分
13件の学習用教材
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Glossary Week 210 分
13の練習問題
Pre-lecture Questions4 分
Practice Quiz4 分
Pre-lecture Questions6 分
Practice Quiz4 分
Pre-lecture Questions4 分
Practice Quiz4 分
Pre-lecture Questions4 分
Practice Quiz2 分
Pre-lecture Questions4 分
Practice Quiz4 分
Pre-lecture Questions2 分
Practice Quiz4 分
Populational Genetics14 分
3
3時間で修了

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
6件のビデオ (合計51分), 10 readings, 11 quizzes
6件のビデオ
Linkage Analysis. Family Studies11 分
NGS for Studying Monogenic Disorders — Part I7 分
NGS for Studying Monogenic Disorders — Part II10 分
NGS for Studying Monogenic Disorders — Part III11 分
Week 3 Conclusion1 分
10件の学習用教材
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Mendelian disorders: discussion10 分
Glossary Week 310 分
11の練習問題
Pre-lecture Questions2 分
Practice Quiz2 分
Pre-lecture Questions2 分
Practice Quiz2 分
Pre-lecture Questions2 分
Practice Quiz2 分
Pre-lecture Questions4 分
Practice Quiz2 分
Pre-lecture Questions2 分
Practice Quiz2 分
Mendelian Disorders10 分
4
6時間で修了

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
10件のビデオ (合計88分), 18 readings, 19 quizzes
10件のビデオ
Introduction to Genome-Wide Association Studies. Historical Overview12 分
GWAS Nowadays. Imputations10 分
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11 分
4.5. Population Stratification and its Consequences10 分
4.6. Analysis of Genetically Structured Populations9 分
4.7. Meta-analysis of GWAS Results: Theory and Background6 分
4.8. Quality Control of GWAS Array Data10 分
4.9. Meta-analysis of GWAS Results: Practical Details8 分
Week 4 Conclusion2 分
18件の学習用教材
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Recommended Pre-reading10 分
Additional Materials10 分
Additional Materials10 分
Glossary Week 410 分
19の練習問題
Pre-lecture Questions4 分
Practice Quiz4 分
Pre-lecture Questions2 分
Practice Quiz6 分
Pre-lecture Questions2 分
Practice Quiz2 分
Pre-lecture Questions4 分
Post-lecture Questions4 分
Pre-lecture Questions2 分
Post-lecture Questions4 分
Pre-lecture Questions4 分
Post-lecture Questions6 分
Pre-lecture Questions2 分
Post-lecture Questions4 分
Pre-lecture Questions2 分
Post-lecture Questions2 分
Pre-lecture Questions2 分
Quiz4 分
Complex disorders26 分
4.7
7件のレビューChevron Right

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コースが具体的なキャリアアップにつながった

33%

昇給や昇進につながった

人気のレビュー

by FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

by JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

講師

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Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

ノヴォシビルスク大学(Novosibirsk State University) について

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

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