Are you a living creature? Then, congratulations! You’ve got DNA. But how much do you really know about the microscopic molecules that make you unique?
Why is DNA called the “blueprint of life”?
What is a “DNA fingerprint”?
How do scientists clone DNA?
What can DNA teach you about your family history?
Are Genetically Modified Organisms (GMOs) safe?
Is it possible to revive dinosaurs by cloning their DNA?
DNA Decoded answers these questions and more. If you’re curious about DNA, join Felicia Vulcu and Caitlin Mullarkey, two biochemists from McMaster University, as they explore the structure of DNA, how scientists cracked the genetic code, and what our DNA can tell us about ourselves. Along the way, you’ll learn about the practical techniques that scientists use to analyze our genetic risks, to manipulate DNA, and to develop new treatments for a range of different diseases. Then, step into our virtual lab to perform your own forensic DNA analysis of samples from a crime scene and solve a murder.
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マックマスター大学（McMaster University）
シラバス - 本コースの学習内容
週
13時間で修了
Cracking the Genetic Code
In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)
7件のビデオ （合計45分）, 4 readings, 6 quizzes
7件のビデオ
How to Speak DNA4 分
Cracking the Genetic Code4 分
The Building Blocks of DNA5 分
Packing it all in!6 分
Summing Up1 分
The Double Helix16 分
4件の学習用教材
Timeline of DNA Discoveries10 分
Behind the Picture: Photo 51 (interview)10 分
(Not Really) The Last Word about DNA (video)10 分
Biochemistry: The Operating System of Life (video)10 分
6の練習問題
How to Speak DNA6 分
Cracking the Genetic Code6 分
The Building Blocks of DNA8 分
Packing it all in!6 分
DNA Word Search2 分
Cracking the Genetic Code22 分
週
23時間で修了
Getting the Message Across: Transcription, Translation, and Replication
We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!
8件のビデオ （合計52分）, 4 readings, 9 quizzes
8件のビデオ
Stop copying me! DNA Replication6 分
Central Dogma, Part I: Transcription8 分
Central Dogma, Part II: Translation7 分
Practical DNA: Polymerase Chain Reaction (PCR)8 分
Practical DNA: Gel Electrophoresis7 分
Summing Up3 分
DNA Replication3 分
4件の学習用教材
The Case of the Silenced Scientist10 分
Labster: Crime Scene Investigation10 分
TED Talk: Drew Barry - Animations of Unseeable Biology (video)10 分
Protein Data Bank10 分
9の練習問題
The Scene of the Crime4 分
Stop copying me! DNA Replication4 分
Central Dogma, Pt 1: Transcription8 分
Central Dogma, Pt 2: Translation6 分
Decipher the Secret Message2 分
Breaking the Code (aka Game of Codons)4 分
Polymerase Chain Reaction (PCR)4 分
Gel Electrophoresis6 分
Getting the Message Across16 分
週
33時間で修了
Manipulating DNA
In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media.
8件のビデオ （合計46分）, 5 readings, 7 quizzes
8件のビデオ
Slice and Dice: Restriction Enzymes10 分
Lights, Camera, Transformations6 分
Mutations, Mutations, Mutations!6 分
From Bananas to Papayas: Genetically Modified Organisms (GMOs)9 分
Summing Up4 分
Genetic Engineering1 分
Sickle Cell Anemia59
5件の学習用教材
Labster: Molecular Cloning Simulation10 分
Creating Dolly (video)10 分
Genetic Engineering and Working with DNA (video)10 分
How did they make insulin from recombinant DNA? (article)10 分
Massive Review Reveals Consensus on GMO Safety (article)10 分
7の練習問題
Freaky Fruit: Manipulating DNA6 分
Slice and Dice: Restriction Enzymes6 分
Lights, Camera, Transformations6 分
Mutations, mutations, mutations6 分
From Papayas to Bananas: Genetically Modified Organisms (GMOs)6 分
Help Felicia design a blue tomato!8 分
Manipulating DNA16 分
週
43時間で修了
DNA and Me
What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA.
9件のビデオ （合計45分）, 7 readings, 6 quizzes
9件のビデオ
Sanger Sequencing3 分
The Human Genome Project5 分
Mammoths, Mummies, and Microbes: Ancient DNA10 分
Me and My Family Tree8 分
DNA and My Health5 分
That's a wrap!5 分
Sanger Sequencing51
Human Genome Sequencing1 分
7件の学習用教材
Labster: Next Generation Sequencing Simulation10 分
Cracking the Code of Life (video)10 分
Iceman Murder Mystery (video)10 分
Personal DNA Testing (video)10 分
My Career in Genomics: Antibiotic Resistance (video)10 分
My Career in Genomics: Cancer Biology (video)10 分
My Career in Genomics: Evolution (video)10 分
6の練習問題
DNA: Our Genetic Blueprint2 分
Sanger Sequencing8 分
Me and My Family Tree4 分
DNA and My Health2 分
DNA and Me18 分
Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)4 分
4.7
18件のレビュー人気のレビュー
The most fun I have ever had with a course! Both professors have an amazing talent for conveying information. I hope that they will teach another class!
Highly recommended!\n\nAwesome method of presenting a classic, boring , course.
講師
Caitlin Mullarkey
Assistant ProfessorHealth Sciences
Felicia Vulcu
Assistant ProfessorBiochemistry and Biomedical Sciences
マックマスター大学（McMaster University）について
Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”.
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