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推奨:6 hours/week...

英語

字幕:英語

100%オンライン

自分のスケジュールですぐに学習を始めてください。

柔軟性のある期限

スケジュールに従って期限をリセットします。

初級レベル

約13時間で修了

推奨:6 hours/week...

英語

字幕:英語

シラバス - 本コースの学習内容

1
2時間で修了

Enzymes, Enzyme Discovery and Engineering

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics. ...
8件のビデオ (合計61分), 2 readings, 1 quiz
8件のビデオ
Introduction from Nigel Scrutton38
Overview and introduction9 分
How do enzymes work?15 分
How do we discover enzymes for application in biotechnology?5 分
How can we study and characterise the catalytic activity of enzymes?7 分
Engineering Enzymes I: Directed Evolution8 分
Engineering Enzymes II: Rational Design of Biocatalysts11 分
2件の学習用教材
Pre Course Survey and Course Credits10 分
Glossary10 分
1の練習問題
Enzymes, Enzyme Discovery and Engineering22 分
2
2時間で修了

Methods in Systems and Synthetic Biology

Recent advances in our ability to read and write genome sequences on a large scale have led to an ambitious vision for a new generation of biotechnology, often referred to as Synthetic Biology. Synthetic Biology aims at turning biology into an engineering discipline, in which organism engineers use computational tools to design biological systems with novel valuable functionalities, which are then built using advanced high-throughput genetic engineering, and tested by rapid screening technologies that collect diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle. This module will introduce the engineering concepts that inform Synthetic Biology and the cutting-edge technologies that underlie our dramatically increasing ability to construct living systems with custom-made functionalities. All stages of the design-build-test cycle for novel biosystems will be discussed, with a special focus on their integration in a unified bioengineering platform. Examples will focus on the application of Synthetic Biology as an enabling technology for the bioindustry, especially for the improved microbial production of high-value chemicals and drugs. A section on responsible research and innovation will explore the transformative potential of this innovative technology within a broader socio-economic context, creating awareness of the ethical and political implications of research in this field....
9件のビデオ (合計61分), 2 readings, 1 quiz
9件のビデオ
Introduction to Synthetic Biology: Visions for Biotechnology 2.06 分
Designing biological systems: Computational modelling and systems biology9 分
Building biological systems I: Genome synthesis and genome editing9 分
Controlling and engineering pathways in Synthetic Biology9 分
Testing Biological Systems Biological debugging using metabolomics8 分
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics I5 分
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics II6 分
Conclusions and Outlook Systems and Synthetic Biology6 分
2件の学習用教材
Glossary10 分
Systems and Synthetic Biology10 分
1の練習問題
Methods in Systems and Synthetic Biology22 分
3
2時間で修了

Biochemical and Bioprocess Engineering

Biochemical and bioprocess engineering is concerned with the design of processes which involve biological transformations to manufacture a range of bio-based chemicals, biopharmaceuticals and biofuels. Through applying knowledge of process constraints, which are usually described mathematically, biochemical engineers are able to design a series of integrated process steps or “unit operations” which together make up a bioprocess. This module will give an appreciation of the key role biochemical engineering has in translating discoveries coming from life sciences and synthetic biology, such as improved microbial platforms for product expression, into economically viable full scale production processes. Key engineering concepts and the problem solving approach required for the design of bioprocesses will be taught by a group of biochemical engineers from The University of Manchester, University College London and Technical University of Denmark....
8件のビデオ (合計90分), 1 quiz
8件のビデオ
Introduction from James Lawrence and Michael Sulu45
Introduction to Biochemical and Bioprocess Engineering12 分
Microbial fermentation processes and bioreactor design10 分
Biocatalysis and enzymatic processes24 分
Recovery and purification of small molecules11 分
Recovery and purification of large molecules9 分
Process economics and scale-up19 分
1の練習問題
Biochemical and Bioprocess Engineering24 分
4
2時間で修了

Pharmaceuticals and Fine Chemicals

This module looks at the production of pharmaceuticals and fine chemicals using biocatalysis. Specifically, we will look at isolated biocatalytic transformations using isolated enzymes or whole cells as catalysts to manufacture commercially important products including pharmaceuticals, industrial monomers and personal care products. This module will be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership dedicated to the development of manufacturing sustainable pharmaceuticals led by The University of Manchester and the pharmaceutical company GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The University of York, will look at six industrial examples of biocatalytic reactions involving six different enzyme transformations. Each example will look at the product, manufacturing route, mechanism of the enzyme reaction and some of the sustainability drivers and metrics for adopting IB as part of the manufacturing route. Over the six examples, a number of key attributes of enzyme catalysed processes that need to be considered for successful scale-up will be examined. These include choice of free enzyme or whole cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Each example will have a number of references to the primary literature covering the product and enzyme type for further learning outside of the module....
7件のビデオ (合計66分), 2 readings, 1 quiz
7件のビデオ
Industrial Example 1: Hydrolases11 分
Industrial Example 2: Transaminase11 分
Industrial Example 3: DERA Aldolase10 分
Industrial Example 4: Alcohol Dehydrogenases12 分
Industrial Example 5: Nitrile Hydratases8 分
Industrial Example 6: Amino Acid Oxidases9 分
2件の学習用教材
CHEM2110 分
References and Further Reading10 分
1の練習問題
Pharmaceuticals and Fine Chemicals24 分
5
2時間で修了

Case Studies: Bioenergy and Biomaterials

Bioenergy is renewable energy extracted from biomass (organic biological material such as plants and animals, wood, waste, (hydrogen) gas, and alcohol fuels. Biomass is the fuel, bioenergy is the energy contained within that fuel. In this module we will look at biofuel production and the research and knowledge challenges associated with increasing the contribution of UK bioenergy to meet strategic environmental targets in a coherent, sustainable and cost-effective manner. In addition, we will be looking at biomaterials science and, in particular, the development of novel biomaterials and their application in a variety of industrial and medical products. Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite materials. As a science it is around 50 years old so we will be considering the current trends and the future of biomaterials research and biomanufacturing technologies....
7件のビデオ (合計80分), 2 readings, 1 quiz
7件のビデオ
The challenges of sustainable bioenergy development12 分
New routes to biofuel production18 分
Membrane processes in industrial biotechnology13 分
Enzymatic biofuel cells11 分
Biomaterials: engineering cell niches hydrogels14 分
Biomanufacturing8 分
2件の学習用教材
Reading List10 分
Glossary10 分
1の練習問題
Case Studies: Bioenergy and Biomaterials24 分
6
2時間で修了

Case Studies: Glycoscience and Biotherapeutics

Glycoscience is the science and technology of carbohydrates, which are the most abundant biological molecules on Earth and make up part of the biology of all living organisms. This module will introduce the fundamental concepts of glycoscience, leading onto the benefits for society and how this drives and impacts the bioeconomy. A series of case studies will be used to present some of the key challenges and glycan-based solutions in pharmaceuticals and personalised medicine, food security and biomaterials. Biopharmaceuticals are new medicines that are made biologically. “Biologically” means that the production is too complex for simple chemistry and that we currently have to direct biological materials – cells, using the spectrum of natural catalytic reactions - to make these revolutionary medicines. We will be looking at the revolution in these development medicines within a clinical, societal and economic context and the approaches used to ensure production of safe and effective biopharmaceuticals, using various types of expression systems. Students will be introduced to detailed case studies that illustrate how the principles developed in other sub-modules are put into practice in the industrial context....
8件のビデオ (合計71分), 1 quiz
8件のビデオ
Introduction from Alan Dickson1 分
Introduction to glycoscience4 分
Glycoscience: pharmaceuticals & personalised medicines9 分
Glycoscience: other applications11 分
Biopharmaceuticals: the clinical significance10 分
Biopharmaceuticals: the technical stuff15 分
Biopharmaceuticals: the industrial perspective15 分
1の練習問題
Glycoscience26 分
4.7
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人気のレビュー

by JQAug 7th 2017

I really enjoyed this course and although I am not a chemist nor a research biotech guy, I am a dentist that enjoyed the opportunity to learn more about industrial biotechnology. Thanks so much!

by MBJan 28th 2018

Awesome intro to modern technologies and production processes used in the Biotech Industry! Does a great job of detailing where the industry is headed in the upcoming years.

講師

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Prof. Nicholas Turner

Deputy Director
Manchester Institute of Biotechnology
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Prof. Nigel Scrutton

Director
Manchester Institute of Biotechnology

マンチェスター大学(University of Manchester) について

Tracing its roots back to 1824, the University of Manchester is home to almost 40,000 students. The University has three Nobel laureates among its current staff – more than any other British university - and a total of 25 Nobel laureates have come from our past and present students and staff. We have three main goals: to undertake world-class research; to deliver an outstanding learning and student experience; and to be socially responsible....

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