Join Us in a Top 50 MOOC of All Time!
How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth?
When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science.
Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional!
Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video.
You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website.
Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!
この専門講座について
習得するスキル
Whole Genome SequencingViterbi AlgorithmSuffix TreePython ProgrammingAlgorithmsUnweighted Pair Group Method with Arithmetic Mean (UPGMA)Bioinformatics
専門講座のしくみ
コースを受講しましょう。
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実践型プロジェクト
すべての専門講座には、実践型プロジェクトが含まれています。専門講座を完了して修了証を獲得するには、成功裏にプロジェクトを終了させる必要があります。専門講座に実践型プロジェクトに関する別のコースが含まれている場合、専門講座を開始するには、それら他のコースをそれぞれ終了させる必要があります。
修了証を取得
すべてのコースを終了し、実践型プロジェクトを完了すると、修了証を獲得します。この修了証は、今後採用企業やあなたの職業ネットワークと共有できます。
この専門講座には7コースあります。
コース1
Finding Hidden Messages in DNA (Bioinformatics I)
4.7
432件の評価
Named a top 50 MOOC of all time by Class Central!
This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat.
In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome.
In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems.
Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection.
コース2
Genome Sequencing (Bioinformatics II)
4.8
183件の評価
You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome?
Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics.
In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together.
In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab.
Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance.
コース3
Comparing Genes, Proteins, and Genomes (Bioinformatics III)
4.7
84件の評価
Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different.
In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins.
In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question.
Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.
コース4
Molecular Evolution (Bioinformatics IV)
4.6
43件の評価
In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time.
In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans.
In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination.
Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines.
講師
Pavel Pevzner
ProfessorDepartment of Computer Science and Engineering
Phillip Compeau
Visiting ResearcherDepartment of Computer Science & Engineering
Nikolay Vyahhi
Visiting ScholarDepartment of Computer Science and Engineering
カリフォルニア大学サンディエゴ校について
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory.
よくある質問
返金ポリシーについて教えてください。
1つのコースだけに登録することは可能ですか？
はい。まず始めに興味のあるコースカードをクリックして登録します。コースに登録して修了することによって、共有できる修了証を取得するか、無料でコースを聴講してコースの教材を確認することができます。専門講座の一部であるコースにサブスクライブすると、専門講座全体に自動的にサブスクライブされます。進捗を追跡するには、受講生のダッシュボードにアクセスしてください。
学資援助はありますか？
無料でコースを受講できますか？
このコースは100%オンラインで提供されますか？実際に出席する必要のあるクラスはありますか？
このコースは完全にオンラインで提供されているため、実際に教室に出席する必要はありません。Webまたはモバイル機器からいつでもどこからでも講義、学習用教材、課題にアクセスできます。
Are there any suggested readings for the Specialization?
The print companion accompanying the Specialization is Bioinformatics Algorithms: An Active Learning Approach (Vols. 1 and 2).
専門講座を修了するのにどのくらいの期間かかりますか？
Time to completion can vary based on your schedule, but most learners are able to complete the Specialization in 4-6 months.
What background knowledge is necessary?
We require only a basic knowledge of high school-level biology and the ability to think technically.
Do I need to take the courses in a specific order?
We recommend taking the courses in the order presented, as each subsequent course will build on material from previous courses.
専門講座を修了することで大学の単位は付与されますか？
Coursera courses and certificates don't carry university credit, though some universities may choose to accept Specialization Certificates for credit. Check with your institution to learn more.
What will I be able to do upon completing the Specialization?
You will understand the ideas behind many different software tools that are used every day by biotech researchers, and you will know how to apply these tools to real datasets.
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