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約30時間で修了

推奨:7 weeks of study, 6-8 hours/week...

英語

字幕:英語, スペイン語

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CancerMolecular BiologyCancer EpigeneticsDna Methylation

100%オンライン

自分のスケジュールですぐに学習を始めてください。

柔軟性のある期限

スケジュールに従って期限をリセットします。

約30時間で修了

推奨:7 weeks of study, 6-8 hours/week...

英語

字幕:英語, スペイン語

シラバス - 本コースの学習内容

1
2時間で修了

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability. ...
7件のビデオ (合計65分), 5 readings, 1 quiz
7件のビデオ
1.1 Introduction to the concepts of epigenetic control10 分
1.2 Mitotic heritability of epigenetic marks10 分
1.3 Chromatin and the nucleosome6 分
1.4 Chromatin compaction - heterochromatin versus euchromatin9 分
1.5 DNA methylation at CpG islands11 分
1.6 DNA methylation at intergenic regions and repetitive elements15 分
5件の学習用教材
Course syllabus10 分
Teaching team10 分
Start of course survey10 分
Assessment and grading policy10 分
Week 1 and 2 resources10 分
1の練習問題
Week 1 quiz - contributes 8% towards your final grade20 分
2
2時間で修了

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course. ...
9件のビデオ (合計90分), 1 reading, 1 quiz
9件のビデオ
2.2 Histone acetylation and histone methylation12 分
2.3 Chromatin remodelling12 分
2.4 Histone variants8 分
2.5 Noncoding RNAs - microRNAs6 分
2.6 Noncoding RNAs - piRNAs9 分
2.7 Noncoding RNAs - long noncoding RNAs introduction10 分
2.8 Long noncoding RNAs Xist and HOTAIR7 分
2.9 3D organisation of the nucleus and summary of epigenetic marks17 分
1件の学習用教材
Week 1 and 2 resources10 分
1の練習問題
Week 2 quiz - contributes 8% towards your final grade20 分
3
3時間で修了

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms. ...
12件のビデオ (合計113分), 1 reading, 1 quiz
12件のビデオ
3.2 Timing of random and imprinted X chromosome inactivation8 分
3.3 Stages of X inactivation - counting and control of Xist expression13 分
3.4 Control of Xist expression by pluripotency factors6 分
3.5 Stages of X inactivation - choice of which X to inactivate9 分
3.6 Stages of X inactivation - initiation and spreading of silencing11 分
3.7 Stages of X inactivation - establishment of silencing6 分
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18 分
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18 分
3.10 X chromosome inactivation summary10 分
3.11 Dosage compensation in flies and worms, compared with mammals8 分
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10 分
1件の学習用教材
Week 3 resources (including required readings)10 分
1の練習問題
Week 3 quiz - contributes 12% towards your final grade30 分
4
2時間で修了

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth....
6件のビデオ (合計68分), 1 reading, 1 quiz
6件のビデオ
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11 分
4.3 Location of imprinted genes in the genome and bisulfite sequencing10 分
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17 分
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13 分
4.6 Summary of epigenetic reprogramming and imprinting6 分
1件の学習用教材
Week 4 resources (including required reading)10 分
1の練習問題
Week 4 quiz - contributes 12% towards your final grade30 分
4.8
112件のレビューChevron Right

17%

コース終了後に新しいキャリアをスタートした

31%

コースが具体的なキャリアアップにつながった

12%

昇給や昇進につながった

人気のレビュー

by MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

by DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

講師

Avatar

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

メルボルン大学(The University of Melbourne)について

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

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