While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics.
提供：
Epigenetic Control of Gene Expression
????????The University of Melbourne?
このコースについて
36,285 最近の表示
受講生の就業成果
33%
コース終了後に新しいキャリアをスタートした
38%
コースが具体的なキャリアアップにつながった
11%
昇給や昇進につながった
習得するスキル
CancerMolecular BiologyCancer EpigeneticsDna Methylation
受講生の就業成果
33%
コース終了後に新しいキャリアをスタートした
38%
コースが具体的なキャリアアップにつながった
11%
昇給や昇進につながった
100%オンライン
自分のスケジュールですぐに学習を始めてください。
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約30時間で修了
推奨：7 weeks of study, 6-8 hours/week
英語
字幕：英語, スペイン語
提供：
????????The University of Melbourne?
The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University.
シラバス - 本コースの学習内容
2時間で修了
Week 1 - Introduction to Epigenetic Control
An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.
2時間で修了
7件のビデオ （合計65分）, 5 readings, 1 quiz
7件のビデオ
1.1 Introduction to the concepts of epigenetic control10 分
1.2 Mitotic heritability of epigenetic marks10 分
1.3 Chromatin and the nucleosome6 分
1.4 Chromatin compaction - heterochromatin versus euchromatin9 分
1.5 DNA methylation at CpG islands11 分
1.6 DNA methylation at intergenic regions and repetitive elements15 分
5件の学習用教材
Course syllabus10 分
Teaching team10 分
Start of course survey10 分
Assessment and grading policy10 分
Week 1 and 2 resources10 分
1の練習問題
Week 1 quiz - contributes 8% towards your final grade20 分
2時間で修了
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.
2時間で修了
9件のビデオ （合計90分）, 1 reading, 1 quiz
9件のビデオ
2.2 Histone acetylation and histone methylation12 分
2.3 Chromatin remodelling12 分
2.4 Histone variants8 分
2.5 Noncoding RNAs - microRNAs6 分
2.6 Noncoding RNAs - piRNAs9 分
2.7 Noncoding RNAs - long noncoding RNAs introduction10 分
2.8 Long noncoding RNAs Xist and HOTAIR7 分
2.9 3D organisation of the nucleus and summary of epigenetic marks17 分
1件の学習用教材
Week 1 and 2 resources10 分
1の練習問題
Week 2 quiz - contributes 8% towards your final grade20 分
3時間で修了
Week 3 - Dosage Compensation
X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.
3時間で修了
12件のビデオ （合計113分）, 1 reading, 1 quiz
12件のビデオ
3.2 Timing of random and imprinted X chromosome inactivation8 分
3.3 Stages of X inactivation - counting and control of Xist expression13 分
3.4 Control of Xist expression by pluripotency factors6 分
3.5 Stages of X inactivation - choice of which X to inactivate9 分
3.6 Stages of X inactivation - initiation and spreading of silencing11 分
3.7 Stages of X inactivation - establishment of silencing6 分
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18 分
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18 分
3.10 X chromosome inactivation summary10 分
3.11 Dosage compensation in flies and worms, compared with mammals8 分
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10 分
1件の学習用教材
Week 3 resources (including required readings)10 分
1の練習問題
Week 3 quiz - contributes 12% towards your final grade30 分
2時間で修了
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.
2時間で修了
6件のビデオ （合計68分）, 1 reading, 1 quiz
6件のビデオ
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11 分
4.3 Location of imprinted genes in the genome and bisulfite sequencing10 分
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17 分
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13 分
4.6 Summary of epigenetic reprogramming and imprinting6 分
1件の学習用教材
Week 4 resources (including required reading)10 分
1の練習問題
Week 4 quiz - contributes 12% towards your final grade30 分
レビュー
4.8
EPIGENETIC CONTROL OF GENE EXPRESSION からの人気レビュー
MMによりOct 1, 2018
This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.
DSによりAug 24, 2018
This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!
HDによりNov 24, 2019
Update the reading for the final assignment. It is too old and updating it would be an easy fix. I am not going to finish the certificate as the final paper is 7 years ago. Go Boomer. Sad
BMによりAug 13, 2017
One of the best organized and implemented courses I have taken so far. For someone who had barely any experience with epigenetics, I feel this gave me a proper introduction to the field.
HHによりDec 17, 2016
A quintessential course for Genetics students all over the world. Very nicely prepared and elucidated by Dr. Marnie Blewitt .\n\nMany many thanks to Dr. Marnie Blewitt & Coursera team.
TWによりAug 23, 2017
Very informative! Before starting this course I didn't even know epigenetics was a word. Now I feel I have a very good grasp of the basics of one of the core concepts of genetics.
DBによりSep 27, 2016
This was an AWESOME course. Really exciting, interesting, AND surprising, I never thought there's that much to talk about in epigenetics! I'm going to recommend it, definitely :)
VSによりAug 7, 2018
A very informative course which starts from the basics and goes up all the way and the pace of the course is also perfectly set for anyone from professionals to first-timers.
ZLによりDec 11, 2016
Well constructed course and carefully designed questions. It is very useful for someone with biological and/or biomedical background to expand their knowledge on epigenetics!
LMによりJun 18, 2016
The course is very interesting for those who like Genetics. The lectures are delivered in an understandable manner, and the motion pictures make everything clear right away.
AAによりNov 26, 2019
The lectures were enlightening and easy to follow and understand. there were also a lot of examples that made the lectures easy to understand. I totally loved and enjoyed it
ASによりJul 20, 2019
A great learning platform. This was my first ever course on coursera and I've thoroughly enjoyed it. A big thank you to Dr. Marnie Blewitt for helping us learn in a fun way!
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